Lecture 12: Introduction to identification of genetic basis of adaptation
Reading for Feb 26: Cairns et al. (1998) The origin of mutants. Nature 335: 142-145
Reading for March 3 & 5: Bjedov et al. (2003) Stress-induced mutagenesis in bacteria. Science 300: 1404-1409
Reading for March 31 / April 2: Lieberman et al. (2011) Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. Nature Genetics 43: 1275-1281. For some background, see also: Lenski R.E. (2011) Chance and necessity in the evolution of bacterial pathogen. Nature Genetics 43: 1174-1176.
Reading for April 7 & 9: Kurenbach et al. (2015) Sublethal exposure to commercial formulations of the herbicides Dicamba, 2,4-dichlorophenoxyacetic acid, and glyphosphate cause changes in antibiotic susceptibility in Escherichia coli and almonella enteric server Typhimurium. mBio 6: e00009-15. Presentation in popular press: www.theguardian.com/lifeandstyle/2015/mar/24/pesticides-antibiotic-resistance-study
General Reading/Study Materials:
Brownell SE et al. (2014) How students think about experimental design: Novel conceptions revealed by in-class activities. Bioscience 64: 125-137. Discussion of the 'intermediate' experimental design and analysis in-class test.
Hurlbert SH (1984) Pseudoreplication and the design of ecological experiments. Ecological Monographs 54: 187-211. General argument for the importance of properly accounting for experimental design before drawing conclusions
Marvier M (2002) Improving risk assessment for nontarget safety of transgenic crops. Ecological Applications 12: 1119-1124. Demonstration of the importance of not interpreting an absence of evidence as evidence of absence.
Grading rubric (use as is useful for peer-review of other students work)